England defender Gary Cahill has been ruled out of Euro 2012 with a double fracture of his jaw.
The Chelsea centre-half suffered the injury when he collided with goalkeeper Joe Hart during the friendly win over Belgium on Saturday.
Liverpool’s Martin Kelly has been called up as his replacement, subject to Uefa’s approval.
Fellow defender John Terry’s hamstring injury has been given the all-clear after a scan.
An FA statement said: “Cahill has two fractures of his jaw, one either side.
“The England medical team have been in close contact overnight with Cahill’s club doctors who will treat him moving forward.”
England manager Roy Hodgson had already lost goalkeeper John Ruddy (fractured finger) as well as midfielders Gareth Barry (abdomen) and Frank Lampard (thigh) from his original 23-man squad.
Liverpool full-back Kelly made his international debut as a substitute against Norway last weekend, and the 22-year-old has been called up ahead of the more experienced Micah Richards and Rio Ferdinand.
Former captain Ferdinand has won 81 caps for his country but was left out of Hodgson’s initial squad.
Who is Martin Kelly?
• Born 27 Apr 1990
• 47 appearances for Liverpool
• 1 goal
• 1 England cap versus Norway 26/05/2012
• 6 caps for England U21s
• 4 caps for U20s
• 5 appearances for U19s
“To treat a player that has captained and served his country 81 times (in this manner) is nothing short of disgraceful,” said Ferdinand’s representative Jamie Moralee after the latest ommission.
Cahill looked in line to start alongside Chelsea team-mate Terry against France in England’s Euro 2012 opener in Donetsk on 11 June, but his absence now opens the door for either Manchester City’s Joleon Lescott or Everton’s Phil Jagielka.
Manchester United’s Phil Jones is the only other recognised central defender – though he may be needed in midfield following the injuries to Lampard and Barry.
Cahill collided with Hart after a push from Belgium winger Dries Mertens in the 17th minute at Wembley.
Hodgson said after the game: “I wasn’t too happy about the challenge.
“When a striker is chasing a defender who is feeding a ball to the goalkeeper, those nudges and pushes take the defender into the goalkeeper.
“It is something if you have been a goalkeeper you take very unkindly to.
“The referee gave him a yellow card, which he deserved.”
PSV winger Mertens has apologised on his Twitter page.
He said: “I sincerely apologize for the harm I’ve cost to Cahill.
“When in the heat of the moment, you often don’t think about the consequences.
“My thoughts go out to him and I hope he recovers well!”
Kelly’s call-up means that there are now six Liverpool players in the 23-man squad travelling to Ukraine and Poland – more than from any other club